Sentinel

Transforming pathogen surveillance through innovative technology and local empowerment
billboard image Sentinel

Our Problem

Infectious diseases kill millions of people every year, disrupt regional security and economic stability, and can escalate into global crises. The Ebola outbreak in West Africa, the global SARS-CoV-2 pandemic, and the most recent mpox emergency highlight serious vulnerabilities in our health, surveillance, and response systems. Some of the most glaring shortcomings have been in the lack of low-cost, accurate, widely available diagnostic tests, surveillance tools, and digital infrastructure needed to guide public health decisions.

Despite the continued threat of epidemics, we still do not know what pathogens are circulating and lack the tools to monitor how they are spreading. The Sentinel program seeks to overcome this challenge by enabling effective pathogen surveillance, outbreak response, and ultimately prevention of pandemics through the bottom-up empowerment of communities.

Our Solution

Sentinel transforms infectious disease surveillance and response through cutting-edge technology, global collaboration, and local empowerment. Our mission: to preempt outbreaks to save lives and strengthen global health security. The Sabeti Lab at the Broad Insitute and Institute of Genomics and Global Health, Redeemer’s University (IGH) (formerly ACEGID) developed the Sentinel system for the early detection and containment of infectious disease outbreaks, relying on three pillars: detect, connect, and empower.

  • Detect advances in state-of-the-art pathogen detection technology by creating high-performance tests for deadly infectious diseases supported by an accelerated AI-based design process.
  • Connect facilitates the development and implementation of powerful computational tools that can track and monitor outbreaks in real-time, enabling communities to make their own decisions about public health response.
  • Empower focuses on training local scientists and public health officials to leverage technologies that will enable them to carry out locally directed outbreak response.

We have already trained more than 2,500 public health workers from 53 of 54 countries in Africa and supported outbreak response for several deadly diseases, but our work is far from over. Over the next five years, we will strengthen our existing framework in Nigeria and Sierra Leone, moving from a regional to a national system. In parallel, we will extend Sentinel’s geographic reach across Africa beginning with the Democratic Republic of Congo and Senegal. By expanding in both depth and breadth, Sentinel will amplify its impact, enhancing resilience, preparedness, and response. The result will be a stronger global network capable of early detection of and response to outbreaks to prevent pandemics.

Team & Project Resources

Led by Dr. Pardis Sabeti at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, and Dr. Christian Happi at the Institute of Genomics and Global Health, Redeemer’s University (formerly ACEGID) in Ede, Nigeria, Sentinel unites public health experts and scientists to strengthen disease surveillance with genomic and computational tools, world class training, and local empowerment across West Africa.

  • Pardis Sabeti, Professor, Harvard University
  • Christian Happi, Director, Institute of Genomics and Global Health, Redeemer’s University (formerly ACEGID)
  • Al Ozonoff, Associate Professor, Harvard Medical School
Sabeti Lab

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ACEGID

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