MacArthur Fellows Program

MacArthur Fellows / Meet the Class of 2004

Joseph DeRisi

Molecular Biologist

Associate Professor of Biochemistry and Biophysics

University of California, San Francisco

San Francisco, CA

Age: 35

Published September 28, 2004
Portrait of Joseph DeRisi

Joseph DeRisi is a molecular biologist who develops and uses new technologies for exploring the complex, interdependent pathways regulating gene expression. He extends the impact of recent advances in DNA sequencing by examining not just the population of genes within a cell, but also their interactions that lead to complex behaviors. DeRisi uses glass slides, carefully prepared with spots of DNA, arranged by robotic devices in a microarray, to make hundreds and even thousands of measurements of individual gene expression from a single experimental sample. His studies on the most common type of malaria parasite have revealed an unusual pattern of synchronized gene activity. This observation suggests that the infectious agent may be particularly sensitive to drugs that disrupt the gene synchronization necessary to move into the next phase of its life cycle. DeRisi has also demonstrated the power of microarrays for rapid characterization of unknown viral strains; he and colleagues used this method to identify and characterize a novel coronavirus responsible for the outbreak of Severe Acute Respiratory Syndrome (SARS) in early 2003. By enhancing methods for bulk measurement of gene activity and applying this technology to questions of vital biological and medical interest, DeRisi demonstrates the vast potential for discoveries in molecular genetics to decode the mysteries of cellular function and to advance the diagnosis and treatment of disease.

Joseph DeRisi received a B.A. (1992) from the University of California, Santa Cruz, and a Ph.D. (1999) from Stanford University. He was a postdoctoral fellow (1999–2000) and an assistant professor (2000–2004) in the Department of Biochemistry and Biophysics at the University of California, San Francisco; in 2004, he was promoted to his current position as an associate professor. His research has been published in such academic journals as Science, Nature Medicine, Proceedings of the National Academy of Sciences USA, and PLoS Biology.

Photos

Hi-res photos for download. Photos licensed under a Creative Commons license. Courtesy of the John D. & Catherine T. MacArthur Foundation. Right-click on the links below to save the file to your computer.

About the Fellows Program

The MacArthur Fellows Program awards unrestricted fellowships to talented individuals who have shown extraordinary originality and dedication in their creative pursuits and a marked capacity for self-direction. Learn More

Ai-jen Poo, Labor Organizer

Class of 2014

Review Affirms Impact and Inspiration of MacArthur Fellows Program thumbnail

Review Affirms Impact and Inspiration of MacArthur Fellows Program

“We are proud of the Fellows Program and its impact on the lives of not just those selected but people all over the world." Cecilia Conrad, Vice President, MacArthur Fellows program. Read More
"Five Myths About the MacArthur ‘Genius Grants’" thumbnail

"Five Myths About the MacArthur ‘Genius Grants’"

Commentary by Cecilia Conrad originally published in the Washington Post Read More